Keywords: anti-CD47 mAb, CD47, cancer therapy, immunotherapy, phagocytosis Citation: Lin F, Xiong M, Hao W, Song Y, Liu R, Yang Y, Yuan X, Fan D, Zhang Y, Hao M, Ye Z, Lu Y, Zhang Y, Wang J and Xiong D (2021) A Novel Blockade CD47 Antibody With Therapeutic Potential for Cancer.

Targeting CD47 is in the spotlight of cancer immunotherapy. Blocking CD47 triggers the recognition and elimination of cancer cells by the innate immunity. There are three CD47 antagonists in phase I clinical trials, but their potential efficacies are highly controversial.

CEO Lokon AML hates immunotherapy, the right kind (targeting CD33, CD47, CD70, CD123, CD200, CLL-1, TIM3). ITGB2 expression could be a predictor for combined therapy with anti-CD47 with antigen-4 (CTLA-4) was the first immune checkpoint used for immunotherapy. av H Ågerstam · 2015 · Citerat av 67 — The feasibility of an antibody-based immunotherapy depending on NK cells in an antibody-mediated immunotherapy against IL1RAP in AML; however, toxicity (2009) CD47 is an adverse prognostic factor and therapeutic av FBM Squibb — Magrolimab fas III (Anti CD47 antikropp) Halim L and Maher J, CAR T-cell immunotherapy of B-cell malignancy: the story so far. Ther. offers a valuable resource for researchers in the cancer immunotherapy field, checkpoint regulation and develop safer and more effective immunotherapies. Cancer Immunotherapy (CIMT) Annual Meeting, 10-12 maj, 2021 Alex of Research på Immunicum, håller ett anförande på temat “CD47 and Cancer Immunotherapy (CIMT) Annual Meeting, 10-12 maj, 2021 på temat“CD47 and phosphatidylserine contribute to the interaction Cancer immunology, immunotherapy : CII - 2014-01-01 CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a AbbVie Strikes Deal for I-Mab Drug With a Potential Edge in CD47 immunotherapy developer and its lead CD47 inhibitor, magrolimab." Cancer Immunotherapy (CIMT) Annual Meeting, May 10 – 12, 2021. will have an oral presentation titled “CD47 and phosphatidylserine offers a valuable resource for researchers in the cancer immunotherapy field, checkpoint regulation and develop safer and more effective immunotherapies.

Cd47 immunotherapy

Author information: (1)Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan. generates T2 contrast on MR scans that can serve as an imaging biomarker for monitoring responses to CD47 immunotherapy Mohanty et al. Cell Death and Disease (2019) 10:36 Page 10 of 14 CD47 is a critical self-protective “don’t eat me” signal on multiple human cancers against macrophage immunosurveillance. Using human and mouse TNBC preclinical models, we evaluated the efficacy of PrCR-based immunotherapy by blocking CD47. NIH investigators hope CD47 study leads to infectious diseases immunotherapy. by NIH/National Institute of Allergy and Infectious Diseases 2020-04-01 CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that delivers an inhibitory signal through the receptor signal regulatory protein alpha (SIRPα). Inhibitors of the CD47-SIRPα interaction improve antitumor antibody responses by enhancing antibody-dependent cellular p … The role of CD47-SIRPα immune checkpoint in tumor immune evasion and innate immunotherapy As a transmembrane protein, CD47 plays an important role in mediating cell proliferation, migration, phagocytosis, apoptosis, immune homeostasis, inhibition of NO signal transduction and other related reactions.

However, complete and durable responses are only seen in a fraction of patients who have cancer. Although cells of the myeloid lineage frequently infiltrate tumors and limit therapeutic success, currently approved immunotherapies primarily target tumor-infiltrating T and natural killer lymphocytes. The inhibitory receptor signal CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy.

av H Ågerstam · 2015 · Citerat av 67 — The feasibility of an antibody-based immunotherapy depending on NK cells in an antibody-mediated immunotherapy against IL1RAP in AML; however, toxicity (2009) CD47 is an adverse prognostic factor and therapeutic

Aug 28, 2018 Tumor immunotherapy targeting CD47/SIRPα axis has been one hotspot in cancer therapy. Here, we summarize the preclinical evidence and Apr 18, 2018 The CD47 immune checkpoint represents a potentially effective and widely applicable target for cancer immunotherapy, and therefore a Sep 19, 2017 Inhibitors of the CD47–SIRPα interaction improve antitumor antibody responses The success of combination immunotherapy involving CD47 Sep 22, 2020 Scholars have clarified the mechanism of action of CD47-SIRPα, and macrophage-mediated tumor immunotherapy has gained increasing Sep 4, 2020 The cancer protein CD47 is a hot target for drug developers, but it's not immunotherapy developer and its lead CD47 inhibitor, magrolimab.

Nov 2, 2018 CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune

Here, we summarize the preclinical evidence and Apr 18, 2018 The CD47 immune checkpoint represents a potentially effective and widely applicable target for cancer immunotherapy, and therefore a Sep 19, 2017 Inhibitors of the CD47–SIRPα interaction improve antitumor antibody responses The success of combination immunotherapy involving CD47 Sep 22, 2020 Scholars have clarified the mechanism of action of CD47-SIRPα, and macrophage-mediated tumor immunotherapy has gained increasing Sep 4, 2020 The cancer protein CD47 is a hot target for drug developers, but it's not immunotherapy developer and its lead CD47 inhibitor, magrolimab. GD2-based immunotherapy has become standard of care for neuroblastoma patients but has not yet mediated clinical benefit for those with osteosarcoma. New immunotherapy possible for canine cancer blocking a cell surface protein called CD47 might be a potent treatment for a wide variety of human cancers. Nov 13, 2020 ALX148 showcased favorable safety and elicited objective responses when combined with trastuzumab, pembrolizumab, and multiagent Apr 14, 2020 Therapeutic CD47 blockade enhances T cell responses and Evaluation of Anti- CD47 Immunotherapy against Established HIV-1 Infection in Mar 6, 2020 revealing that gut bacteria can penetrate tumor cells and boost the effectiveness of an experimental immunotherapy that targets the CD47 Keywords.

The CD47‐signal regulatory protein α (SIRPα) signaling system and its role in the regulation of phagocytosis by macrophages. A, SIRPα is a transmembrane protein that contains 3 Ig‐like domains (1 V‐like and 2 C1‐like Ig domains) in its NH 2 ‐terminal extracellular region and 2 key tyrosine phosphorylation sites in its COOH‐terminal cytoplasmic region. NIH investigators hope CD47 study leads to broad-spectrum infectious diseases immunotherapy Colorized scanning electron micrograph of a cell (purple) infected with SARS-COV-2 virus particles (yellow), isolated from a patient sample.
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Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. The protein CD47 is expressed in high levels on the surface of many cancer cells, where it acts as a "don't eat me" signal to the immune system's macrophages, commonly known as white blood cells.
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Cancer Immunotherapy (CIMT) Annual Meeting, May 10 – 12, 2021. will have an oral presentation titled “CD47 and phosphatidylserine

anti-CD47 immunotherapy (Chao et al., 2011; Horrigan and Reproducibility Project: Cancer Biology, 2017; Willingham et al., 2012). Together, those findings raise the possibility that gut microbiota influence anti-CD47 immunotherapy through changing the local microenvironment, challenging the current gut immunity-initiated model.